The diagram shows a structural definition of ALS. It raises several questions:
 | What causes the disease to be fatal – is it the degeneration of the neurons, or the weakness of the voluntary muscles? Does it matter where the connection goes? |
| Is the "progressive" taken care of by the spreading and increasing of the weakness? |
| Is putting a probability on the ToDegenerate relation being True of say one in a million useful, or should it be handled some other way, with direct use of the value, rather than mixed up in a Bayesian value? |
| The text says "usually middle age" – should we allow for a different probability either side, or is it already so low it would be meaningless? |
The diagram says 69 network elements, but is actually about 80, allowing for invocation links. The diagram includes an estimate of the time of progression – 2 to 5 years, which the text does not specify, so these elements have not been counted.
It looks like 150 elements would be enough for a disease on average.
A symptom might be –
I can’t lift my arm!
The ability to get from lifting an arm to voluntary muscle weakness will be essential. The use of semantic searching should make that trivial.